genomeboy.com

How will the poem be encoded?

The poem can be most easily encoded by assigning a short, unique sequence of nucleotides to each letter of the alphabet, as Wong has done. But I want my poem to cause the organism to make a protein in response — a protein that also encodes a poem. I am striving to engineer a life form that becomes a durable archive for storing a poem, and a machine for writing a poem — a poem that can survive forever.

Despite my snarky title,  I love that the poet Christian Bök is doing this (subscription only). Anything that defies people’s deterministic ideas about DNA and serves as a bridge between the two cultures is something we should be open to. That said, once this microorganism mutates for a few zillion generations, Bök’s poem could become gobbledygook…or worse.

Three-fourths of the nation’s doctors practice in small offices, with 10 doctors or fewer. For most of them, an investment in digital health records looks like a cost for which they are not reimbursed.It is scarcely surprising, then, that only about 17 percent of the nation’s physicians are using computerized patient records, according to a government-sponsored survey published last year in The New England Journal of Medicine.

“This is really not a technology problem,” observed Erik Brynjolfsson, an economist at the Sloan School of Management at the Massachusetts Institute of Technology. “It’s a matter of incentives and market failure.”

That market failure is a principal target of the Obama administration’s plan. A main feature of the legislation calls for incentive payments of more than $40,000 spread over a few years for a physician who buys and uses electronic health records.

Better late than never. 

Bob, who’s owned wild animals all his life, admits Higgins has not always been a model pet. When Higgins was 3, he slept with the couple, often awakening Bob in the morning by climbing to the bedroom rafters and dropping onto Bob’s stomach. On one occasion, they got in a wrestling match, and Higgins put one of his “steel-like fingernails” through Bob’s scrotum.

Bob has considered moving him to a sanctuary, but “I’m just too attached to him,” he says.

…

Bob has been bitten several times by Higgins, who now weighs 50 pounds and has large incisors. Once, when Bob was leading him from an outdoor enclosure back to his cage in the house, Higgins exploded and the two got into a battle so ferocious that despite the steel mesh glove Bob was wearing, he screamed for Carlie to get his .22 rifle and put a bullet in Higgins’s head. She got Higgins a slice of raisin bread instead, quickly defusing the fight. But Bob accepts it: a wild animal will never be domesticated, he says.

…

“He shivered and I leaned over and said, ‘Come here, baby, are you cold?’ and he exploded,” Ms. Bowers says. “He started biting and screaming at me, biting any place he could touch. It was a nightmare. We tipped over furniture, I would have killed him if I could. But he was so strong. I tried to choke him to make him stop. We fought for I don’t know how long. I was trying to hold him so he couldn’t bite me. I took one of my big fabric books and held it on his throat.”

…

JUDIE HARRISON, 50 and three times married, is an extreme example of monkey love. She once demanded that her 15-year-old son give up his bedroom for a chimp, and today she is estranged from all three of her children because she put the primates first. Her passion also cost her her home.

Words fail. 

Misha Angrist, an assistant professor at the Institute for Genome Sciences and Policy at Duke University, completed his graduate studies with Chakravarti working on the genetic basis of Hirschsprung’s disease. Angrist remembers his mentor as an idea man above all else. “In the 1990s, I used to walk into Aravinda’s office and he’d be sitting there chain smoking and he’d have a yellow pad of paper in front of him and a pencil and he would sit there and…using only his own gray matter, solve a problem [in] population genetics, with no computer and no massive datasets,” Angrist says. “So he comes from this very pure intellectual tradition in genetics.”

I was extremely fortunate to have seven years in the Chakravarti lab, even if I didn’t always appreciate the experience at the time. Read the rest of the tribute to Aravinda here.

I spend many of my waking hours thinking about DNA. Not hydrogen bonds, histones and angstroms per se, but genes and genomes, SNPs, third-generation sequencing, gene patents, genetic testing, privacy, redaction, etc. Consequently, I sometimes get jaded. I take nucleic acids for granted; I think of them as a useful but quotidian aspect of life on earth.

And then I open the newspaper and read this:

Investigators said they are also looking for video accounts of the plane’s brief flight. They have split into teams and invited outside specialists, including some from the Department of Agriculture, who will help analyze the reports about birds. Ms. Higgins said that the engines’ internal parts will generally yield enough DNA to allow investigators to identify not only whether there were birds, but “down to precisely the exact type of bird,” said Ms. Higgins.

Much of the genetic data available direct to consumers is incomplete and preliminary, but in coming years, it will be tested and validated.

God, let’s hope so. Or I, for one, will look pretty stupid.

In any case, I’m looking forward to David Ewing Duncan’s book.

Yeah, baby:

Operation Immortality is a project intended to collect and archive the very best of what humanity has accomplished by sending a digital time capsule of the human race, including messages from people around the world and DNA samples from some of our brightest minds, musicians, athletes and video game players.

Wait a second, dudes…aren’t you forgetting someone?

“This is just a neat human-interest story about a particular couple using the reproductive capabilities they have,” said Mara Kiesling, director of the National Center for Transgender Equality in Washington. “There’s really nothing remarkable” about the Beatie pregnancy, she said.